The Kaspereit Group



Head of group: Prof. Dr.-Ing. habil. Malte Kaspereit

Research statement

Our group develops advanced process concepts, in particular for challenging separation problems. Special focus is on developing novel, high performance processes for difficult and extremely challenging separations. Such problems are found, for example, in the production of pharmaceuticals, biotechnological products, polymers, and fine chemicals.

Investigated technologies comprise, among others,SSR (lab)

  • Chromatography (preparative and analytical; all relevant modes including advanced concepts like simulated moving bed, steady-state recycling, etc.),
  • Membrane processes (like ultra- and nanofiltration, reverse osmosis, and electro-dialysis),
  • Crystallization,
  • Gas adsorption (including PSA and alike).

Application areas are enantioseparations, gas purification, downstream processing of biomolecules, and nanoparticle classification.

Of special interest for us are integrated and reactive separation processes, where we purposefully combine different separation techniques with each other, or with (bio)chemical reactions. Here we systematically develop not only new process concepts, but also computer-based methods and tools for their optimal design and development.

Equipment (selection)

  • Preparative chromatography systems for RP, NP, SEC, chiral chromatography, ion chromatography, ...
  • Membrane test rigs (UF, NF, RO)
  • Electrodialysis unit
  • Analytical HPLC systems (detection by UV, DAD, CAD, MS)
  • Tandem ion chromatography unit coupled to HPLC and MS (trace analysis for mixtures of uncharged and ionic compounds)
  • Gas chromatography
  • Magnetic suspension balance
  • Mass spectrometer

Team Members

Malte Kaspereit
Peter Leicht
Benjamin Reif
Johannes Schmölder

Former Team Members

Jürgen Vargas Schmitz
Sebastian Nimmig
Alexander Günther
Kathleen Müller
Bilal Haider

Selected publications (complete list)

S. Swernath, M. Kaspereit, A. Kienle:
Coupled Continuous Chromatography and Racemization Processes for the Production of Pure Enantiomers,
Chemical Engineering & Technology 37 (2014) 643-651.

D. Flockerzi, M. Kaspereit, A. Kienle:
Spectral properties of Bi-Langmuir isotherms,
Chemical Engineering Science 104 (2013) 957-959.

J. Kiefer, M. Kaspereit:
Determination of the Raman depolarization ratio in optically active samples,
Analytical Methods 5 (2013) 797-800.

S. Nimmig, M. Kaspereit:
Continuous Production of Single Enantiomers at High Yields by Coupling Single Column Chromatography, Racemization, and Nanofiltration,
Chemical Engineering & Processing: Process Intensification 67 (2013) 89-98.

S. Swernath, M. Kaspereit, A. Kienle:
Dynamics and Control of Coupled Continuous Chromatography and Crystallization Processes for the Production of Pure Enantiomers,
Chemical Engineering & Technology 36 (2013) 1417-1429.

M. Kaspereit, S. Swernath, A. Kienle:
Evaluation of competing process concepts for the production of pure enantiomers,
Organic Process Research & Development 16 (2012) 353-363.

M. Kaspereit, T. Sainio:
Simplified Design of Steady-State Recycling Chromatography Under Ideal and Nonideal Conditions,
Chemical Engineering Science
66 (2011) 5428-5438.

J. G. Palacios, M. Kaspereit, A. Kienle:
Integrated Simulated Moving Bed Processes for the Production of Single Enantiomers,
Chemical Engineering & Technology
34 (2011) 688-698.