Integrierte Trennverfahren



Head of group: Prof. Dr.-Ing. habil. Malte Kaspereit

Research statement

The research group develops advanced process concepts, in particular for challenging separation problems. Special focus is on integrated processes which combine different separation techniques with each other and/or with (bio)chemical reactions. Such processes have the potential of achieving drastically improved performance.

We study bothExample: Process combination that produces a pure enantiomer from a racemate at 100% yield hybrid processes (combined separations) as well as reactive separations. Such processes raise interesting challenges regarding their optimal design and dynamic behavior. Against this background, the group applies and develops methods for systematic process development, ranging from model-based and optimization-based process synthesis to shortcut design approaches for fast implementation of developed processes.

Investigated technologies include chromatography, adsorption (PSA), membrane separations, electrodialysis, crystallization, and (bio)chemical reactions. Particular expertise is being held in sophisticated preparative chromatographic concepts, including various variants of batch chromatography, simulated moving bed chromatography, and steady-state recycling.

Application areas include separations of fine chemicals, pharmaceuticals, enantiomers, biomolecules, nanoparticles, and polymers.

Offered services

The group offers services regarding process development and process design, in particular on the basis of the unit operations mentioned above. This includes process modelling, simulation, design, performance evaluation, as well as experimental parameter determination and full characterization of corresponding applications.

Further service is offered in chromatographic analysis and characterization of mixtures. For this purpose, a tandem ion chromatography unit coupled to HPLC chromatography and mass spectrometry is available, which allows also trace analysis of samples that may include ionic compounds.

Team Members

Malte Kaspereit
Johannes Schmölder
Jürgen Vargas Schmitz

Former Team Members

Sebastian Nimmig
Alexander Günther
Kathleen Müller
Bilal Haider

Selected publications (complete list)

S. Swernath, M. Kaspereit, A. Kienle:
Coupled Continuous Chromatography and Racemization Processes for the Production of Pure Enantiomers,
Chemical Engineering & Technology 37 (2014) 643-651.

D. Flockerzi, M. Kaspereit, A. Kienle:
Spectral properties of Bi-Langmuir isotherms,
Chemical Engineering Science 104 (2013) 957-959.

J. Kiefer, M. Kaspereit:
Determination of the Raman depolarization ratio in optically active samples,
Analytical Methods 5 (2013) 797-800.

S. Nimmig, M. Kaspereit:
Continuous Production of Single Enantiomers at High Yields by Coupling Single Column Chromatography, Racemization, and Nanofiltration,
Chemical Engineering & Processing: Process Intensification 67 (2013) 89-98.

S. Swernath, M. Kaspereit, A. Kienle:
Dynamics and Control of Coupled Continuous Chromatography and Crystallization Processes for the Production of Pure Enantiomers,
Chemical Engineering & Technology 36 (2013) 1417-1429.

M. Kaspereit, S. Swernath, A. Kienle:
Evaluation of competing process concepts for the production of pure enantiomers,
Organic Process Research & Development 16 (2012) 353-363.

M. Kaspereit, T. Sainio:
Simplified Design of Steady-State Recycling Chromatography Under Ideal and Nonideal Conditions,
Chemical Engineering Science
66 (2011) 5428-5438.

J. G. Palacios, M. Kaspereit, A. Kienle:
Integrated Simulated Moving Bed Processes for the Production of Single Enantiomers,
Chemical Engineering & Technology
34 (2011) 688-698.